ChIP-seq, ATAC-seq, and chromatin shearing at 96-well scale
PIXUL processes chromatin from 96 samples in parallel, validated in Nucleic Acids Research (2019) with fragment sizes of 440 +/- 53 bp across all wells. Detailed epigenetics application content is coming soon.
Chromatin fragment size across all 96 wells
Nucleic Acids Research, 2019
Validated for epigenetics workflows
PIXUL's uniform chromatin shearing translates directly to epigenetics workflows. Detailed application pages with protocols and data are coming soon.
ChIP-seq
96-well chromatin immunoprecipitation with uniform shearing. Consistent fragment sizes across every well eliminate the positional variability that introduces noise into peak calling and differential binding analysis.
Content coming soonATAC-seq
Consistent chromatin accessibility preparation across all samples on the same plate. Uniform nuclei processing reduces the technical variability that confounds open-chromatin profiling at scale.
Content coming soonCUT&Tag
Integration with Active Motif's CUT&Tag kits for high-throughput targeted chromatin profiling. Parallel processing in standard 96-well plates brings CUT&Tag to population-scale studies.
Content coming soonBisulfite sequencing
Uniform DNA fragmentation for whole-genome bisulfite sequencing. Controlled sonication energy across all 96 wells produces consistent fragment-size distributions, the foundation for accurate methylation mapping.
Content coming soonSame instrument. Same 96-well throughput. Detailed content on the way.
PIXUL already delivers validated chromatin shearing for ChIP-seq, ATAC-seq, CUT&Tag, and bisulfite sequencing workflows. In-depth application pages are coming soon.
Published chromatin shearing data
Peer-reviewed performance data from PIXUL chromatin shearing, published in Nucleic Acids Research (2019).
+/- 53 bp fragment size
Chromatin fragment size distribution across all 96 wells (NAR, 2019)
Samples in parallel
Standard microplate format, all wells processed simultaneously
Minutes per run
Walk-away operation with built-in chilling and temperature control
Per plate consumable cost
Standard microplates, no proprietary consumables required
Source: Nucleic Acids Research, Volume 47, Issue 14, 2019. PIXUL chromatin shearing validation data.
Get notified when epigenetics application content is available
Register your interest now and we will reach out as soon as detailed epigenetics application pages are published for PIXUL.