DNA shearing, NGS library prep, and cfDNA processing at 96-well scale
PIXUL delivers gDNA fragments averaging 307 ± 35 bp across all 96 wells, validated in Nucleic Acids Research (2019). Detailed application content for whole genome sequencing, targeted sequencing, and cell-free DNA liquid biopsy is coming soon.
Coming Soonaverage gDNA fragment size across all 96 wells
Nucleic Acids Research, 2019
Genomics applications for PIXUL
PIXUL's validated DNA shearing performance is the foundation for four genomics application areas. Detailed content for each is coming soon.
Whole Genome Sequencing (WGS)
Uniform gDNA fragmentation across 96 samples in a single run. Consistent fragment size distributions reduce sequencing bias and improve coverage uniformity for population-scale studies.
96-sample parallel shearingTargeted Sequencing
Consistent fragment sizes tuned for panel-based capture assays. Tight size distributions across all wells improve on-target rates and reduce wasted sequencing reads in gene panel workflows.
Optimized for capture panelsNGS Library Prep
96-sample parallel shearing compatible with Illumina and PacBio library preparation workflows. Replace serial probe sonication or enzymatic fragmentation with a single walk-away plate-based step.
Illumina + PacBio compatibleCell-Free DNA (cfDNA)
Liquid biopsy sample processing from plasma at plate scale. Process cfDNA samples in parallel for clinical research applications including cancer detection, prenatal screening, and transplant monitoring.
Liquid biopsy at scalePublished data for genomics applications
PIXUL DNA shearing has been validated in peer-reviewed publications. These metrics form the foundation for all planned genomics applications.
bp fragment size
Average gDNA fragment length across all 96 wells (NAR 2019)
samples in parallel
All wells processed simultaneously in a single run
minutes per run
Walk-away operation with built-in chilling and temperature control
per plate
Standard 96-well consumables, no proprietary plates required
Source: Nucleic Acids Research, Volume 47, Issue 14, 2019. gDNA fragmentation validation data.
The same 2 MHz megasonication platform that proteomics labs rely on, applied to DNA shearing for next-generation sequencing.
PIXUL's arrayed transducer architecture delivers uniform acoustic energy to every well. The result: tight fragment size distributions that translate directly to higher-quality sequencing libraries.
Get notified when genomics application content is available
Be among the first to evaluate PIXUL for your DNA shearing and NGS library prep workflows.